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CURRICULUM VITAE
DR. MALCOLM J. SIMONS MB.ChB, MD (Otago,NZ), DMedSci (Tokyo,Japan), FACA, FRCPA
Date of Birth: 10 December, 1939.
Nationality: New Zealand.
DEGREES/FELLOWSHIPS:
MB.ChB. Bachelor of Medicine, Bachelor of Surgery University of Otago, Dunedin, New Zealand 1962
FRCPA Fellow, Royal College of Pathologists of Australasia 1974
FACA Fellow, Australian College of Allergy 1974
MD Doctor of Medicine (Distinction) University of Otago, Dunedin, New Zealand 1977
D.Med.Sci. Doctor of Medical Science University of Tokyo, Japan 1977
APPOINTMENTS/CONSULTANTSHIPS:
Past:
1. Director of Science, GeneType AG, CH‑6300 Zug, Switzerland 1989-2000
2. Consultant, Simons GeneType Diagnostics Pty Ltd Australia 1989-2000
3. Consultant, Genetic Technologies Ltd, Australia 2000-2003
Present:
1. Founder-Scientist Simons HAPLOMICS Ltd 2003-
Past:
1. Consultant Immunologist, Immunodiagnostic Centre, North Melbourne, Australia. 1968-87
2. Consultant Pathologist, Immunolabs Assays / Analytic Reference Labs, North Melbourne, Australia. 1968-87
3. Consultant Immunopathologist, Immunology (Pathology) Laboratories, Singapore. 1976-87
4. Associate, Department of Pathology and Immunology, Monash University, Prahran, Australia. 1978-87
5. Consultant Immunogeneticist, Immunogene Typing Laboratories, Immunosearch Pty. Ltd., North Melbourne, Australia. 1981-87
6. Consultant Immunogeneticist, Division of Laboratory Medicine, Royal Southern Memorial Hospital, Caulfield, Australia. 1985-89
7. Consultant in Biotechnology, CP Ventures Ltd., Melbourne, Australia. 1985-86
8. Past President/Councillor, 3rd Asia‑Oceania Histocompatibility Workshop Conference, Sapporo, Japan. 1985-86
9. President, 2nd Asia‑Oceania Histocompatibility Workshop Conference, Melbourne, Australia. 1980-81
10. Principal Investigator, Anti‑Cancer Council of Victoria. Immunogenetics & Immunovirology Programme on Cervical Cancer. Prince Henry's Hospital, Melbourne, Australia. 1977-80
11. Scientist and Head, World Health Organisation Immunology Research and Training Centre for the Western Pacific and Southeast Asian regions, National University of Singapore, Singapore. 1970-76
12. Principal Investigator, International Agency for Research on Cancer, Lyon, France / National Cancer Institute, National Institute of Health, U.S.A. Cancer Research Programme, National University of Singapore, Singapore. 1970-76
13. Consultant Immunologist, Division of Serology and Immunology, Institute for Medical Research, Kuala Lumpur, Malaysia. 1974-76
14. WHO Technical Advisory Committee on Dengue Haemorrhagic Fever, Bangkok, Thailand. 1975
15. WHO/University of North Sumatra/Ministry of Health Population Health Survey in Samosir & Nias Islands, North Sumatra, Indonesia. 1974-75
16. WHO Working Group on the Organisation of Comprehensive Cancer Control Programmes in the Western Pacific Region, Manila, Philippines. 1975
17. WHO International Agency for Research on Cancer, Postgraduate Course in Immunovirology of Cancer, Lyon, France. 1974
18. WHO/Indian Council for Medical Research 3rd Annual Immunology Training Course, New Delhi, India. 1974
19. WHO‑Assisted Workshop on Hepatitis B antigen, Tokyo, Japan. 1973
20. WHO Scientific Group on Viral Hepatitis, Geneva, Switzerland. 1972
21. WHO Immunology Workshop for the Southeast Asian Region, Bangkok, Thailand. 1972
22. Singapore Ministry of Health Expert Committee on Australia (Hepatitis B) Antigen Singapore 1971-76
23. Senior Research Fellow, National Health and Medical Research Council, Royal Children's Hospital Research Foundation, Parkville, Australia. 1967-70
24. Research Fellow, National Health and Medical Research Council, Royal Children's Hospital Research Foundation, Parkville, Australia. 1964-67
LEARNED SOCIETIES:
American Society for Histocompatibility and Immunogenetics Australasian and Southeast Asian Tissue Typing Association Australian Society of Immunology and Allergy Inc Australian Medical Association Australian Society for Clinical Ecology Australian Society of Immunology Inc Clinical Immunology Group of Australia Human Genetics Society of Australasia International Epidemiology Association International Society for Haematology International Society for Oncological Biology and Medicine International Union for the Scientific Study of Populations Malaysian Society for Parasitology and Tropical Medicine New York Academy of Sciences Royal Society for Tropical Medicine and Hygiene Royal Society of Medicine Singapore Medical Association Singapore Society for Immunology Society for the Study of Human Biology Transplantation Society of Australia and New Zealand Victorian Society of Pathology and Experimental Medicine
PUBLICATIONS (excluding Abstracts):
1. Simons, M.J. (1962). The effect of massive antigenic stimulation on blood vessels of the rat's brain. Proc. Univ. Otago Med. School, 40, 27.
2. Heslop, B.F. and Simons, M.J. (1962). The concept of Auto‑immunity. N.Z. Med. J., 61, 174.
3. Simons, M.J. (1963). Self‑recognition as a biological mechanism. In: Hemlock, Bull. Cant. Univ. (NZ) Socratic Society (ed. Lorking, D.), 4, 26.
4. Simons, M.J. (1964). Research and teaching in biology. In: Hemlock, Bull. Cant. Univ. (NZ) Socratic Society (ed. Lorking, D.), 5, 16.
5. Simons, M.J. and Fowler,R. (1966). Chorioallantoic membrane lesions produced by inoculation of adult fowl small lymphocytes. Nature, 209, 588.
6. Simons, M.J. (1966). Experimental renal transplantation. Proc. XIth Congr. Int. Soc. Blood Transfusion, pp. 273‑281.
7. Simons, M.J., Schumacher, M.J. and Fowler, R. (1968). Intravenous gammaglobulin therapy of immunoglobulin deficiency diseases. Aust. Paed. J., 4, 127.
8. Simons, M.J., Fowler, R. and Fitzgerald, M.G. (1968). Mechanism of small lymphocyte reactivity induced by PHA in culture: The role of PHA determinants and lymphocyte membrane reactive sites. Nature, 219, 1021.
9. Simons, M.J. (1968). Anti‑lymphocyte serum. Lancet, 1, 866.
10. Simons, M.J. and Fitzgerald, M.G. (1968). Rubella virus and human lymphocytes in culture. Lancet, 2, 937.
11. Simons, M.J. and Jack, I. (1968). Lymphocyte viraemia in congenital rubella. Lancet, 2, 953.
12. Simons, M.J. (1968). Congenital rubella: An immunological paradox? Lancet, 2, 1275.
13. Simons, M.J. (1968). Project ANZ‑ASIA. In: The generation gap and Australian‑Asian relations (ed. Jordens, J.T.F.) Australian‑Asian Association of Victoria, pp. 88‑104.
14. Schumacher, M.J., Dreher, G.H. and Simons, M.J. (1968). Thymic hypoplasia and immunoglobulin synthesis. Aust. Paed. J., 4, 252.
15. Simons, M.J. and Fitzgerald, M.G. (1969). Apparent dissociation of antigen responsiveness and antibody production by small lymphocytes in culture. Clin. exp. Immunol., 4, 55.
16. Simons, M.J., Fowler, R. and Fitzgerald, M.G. (1969). The reactivity of human small lymphocytes in culture: the effect of concentration and duration of exposure to phytohaemagglutinin. Cell. Tiss. Kinet., 2, 1.
17. Simons, M.J. (1970). How to use an Immunology laboratory. Med. J. Aust., 2, 643.
18. Simons, M.J. (1970). Trends in immunoglobulin therapy. Med. J. Aust., 2, 683.
19. Simons, M.J., Hosking, C.S. and Hogarth‑Scott, R.D. (1970). The current status of IgE in allergic reactions. Australasian Ann. Med., 19, 366.
20. Simons, M.J. (1970). ANZ‑ASIA: A human biological view. In: Everyman in Australia. The Octagon lectures (ed. Bolton,G.C.), Univ. Western Australia Press, pp. 54‑66.
21. Blake, N.M., Kirk, R.L., Simons, M.J. and Alpers, M.P. (1970). Genetic variants of soluble malate dehydrogenase in New Guinea populations. Humangenetik, 11, 72.
22. Simons, M.J., Fitzgerald, M.G. and Alpers, M.P. (1971). Lymphocyte function in Kuru. In: Proc. 6th. Congr. Neuropath., Masson, Paris. pp. 825‑826.
23. Simons, M.J., Yap, E.H., Yu, M., Seah, C.S., Chew, B.K., Fung, W.P., Tan, A.Y.O. and Shanmugaratnam, K. (1971). Frequency of Australia antigen in Singapore Chinese patients with hepatocellular carcinoma. Lancet, 1, 1149.
24. Simons, M.J., Ong, Y.W. and Yap, E.H. (1971). Australia antigen in Singapore. III. Significance as a public health problem. In: Proc. 6th Singapore‑Malaysia Congr. Med. (ed. Chew, C.H.), pp. 213‑218.
25. Simons, M.J. (1971). Project ANZ‑ASIA: Further proposals for human population studies. Search (J. Aust. NZ. Assoc. for the Advancement of Science). 2, 369‑376.
26. Fung, W.P., Ong, Y.W., Kwa, S.B., Tan, K.K., Yap, E.H. and Simons. M.J. (1971). Anicteric viral hepatitis in blood donors. Med. J. Aust., 2, 888.
27. Hogarth‑Scott, R.S., Howlett, B.J., McNicol, K.N., Simons, M.J. and Williams, H.E. (1971). IgE levels in the sera of asthmatic children. Clin. exp. Immunol., 9, 467.
28. Hosking, C.S., Fitzgerald, M.G. and Simons, M.J. (1971). Quantified deficiency of lymphocyte response to phytohaemagglutinin in immune deficiency diseases. Clin. exp. Immunol., .
29. Morris, P.J., Ting, A., Alpers, M.P. and Simons, M.J. (1971). Leucocyte antigens in a New Guinea population. Tissue Antigens, 1, 49‑52.
30. Ong, Y.W., Kwa, S.B., Ying, C.S., Yap, E.H. and Simons, M.J. (1971). Australia antigen in Singapore. I. Frequency in blood donors. Singapore Med. J., 12, 189.
31. Ting, A., Wee, G.B., Simons, M.J. and Morris, P.J. (1971). The distribution of HLA leucocyte antigens in Singapore Chinese, Malays and Indians. Tissue Antigens, 1, 258‑264.
32. Yap, E.H., Ee, T.I. and Simons, M.J. (1971). Detection of Australia antigen by electro‑osmodiffusion (EOD). Southeast Asian J. of Trop. Med. Public Health, 2, No. 4, 486.
33. Simons, M.J. (1972). Some recent advances in Immunology ‑or ‑ Immunology goes human: approaches to patient and population Immunology. In: Proc. 7th Malaysia‑Singapore Medical Congr., Kuala Lumpur, (eds. Kutty, K., Ng, K. F. and Mohanadas, A.). pp. 209‑213.
34. Simons, M.J., Binns, C.W., Malcolm, L.A. and Yap, E.H. (1972). Australia antigen in two groups of highland New Guineans. Papua New Guinea Med. J., 15, 91.
35. Simons, M.J. (1972). Australia antigen in hepatocellular carcinoma. Lancet, 2, 1089‑1090.
36. Simons, M.J., Yap, E.H., Yu, M. and Shanmugaratnam, K. (1972). Australia antigen in Singapore Chinese patients with hepatocellular carcinoma and comparison groups: Influence of technique sensitivity on differential frequencies. Int. J. Cancer, 10, 320‑325.
37. Simons, M.J., Yap, E.H., Ong, Y.W., Okochi, K., Mayumi, M. and Nishioka, K. (1972). Frequency of Australia antigen in blood donors in Singapore. Amer. J. Dis. Child.,123, 405.
38. Simons, M.J., Yap, E.H., Yu, M., Seah, C.S., Chew, B.K., Fung, W.P., Tan, A.Y.O. and Shanmugaratnam, K. (1972). Frequency of Australia antigen in Chinese patients in Singapore with hepatocellular carcinoma. Amer. J. Dis. Child., 123, 358.
39. Curtain, C.C. and Simons, M.J. (1972). Tissue binding antibodies in tropical populations. Trans. Roy. Soc. Trop. Med., 66, 292.
40. Curtain, C.C. and Simons, M.J. (1972). Lymphocyte mitogens of indigenous Australian plant species. Int. Arch. Appl. Immunol., 42, 225.
41. Yap, E.H., Ong, Y.W., Simons, M.J., Okochi, K., Mayumi, M. and Nishioka, K. (1972). Australia antigen in Singapore. II. Differential frequency in Chinese, Malays and Indians. Vox. Sang., 22, 371.
42. Zaman, V., Ascheim, L., Yap, E.H. and Simons, M.J. (1972). Detection of malarial antibodies by countercurrent immunoelectrophoresis. Sing. Med. J., 13, 305‑306.
43. Simons, M.J., Kwa, S.B., Day, N.E., Wee, G.B., Hawkins, B.R., de The, G.B. and Shanmugaratnam, K. (1973). Immunogenetic studies of Southeast Asian ethnic groups with high and low risk for NPC. In: Analytic and Experimental Epidemiology of Cancer. Proc. 3rd Int. Cancer Symposium of the Princess Takamatsu Cancer Research Fund (eds. Nakahara, W., Hirayama, T., Nishioka, K. and Sugano, H. ). Univ. of Tokyo Press, Tokyo, pp. 171-193.
44. Simons, M.J., Detection of AFP by radioelectro-complexing (1973). Tumour Research, 8, 37.
45. Simons, M.J., Yu, M. and Shanmugaratnam, K. HB Antigenaemia, specific immune deficiency and hepatocellular carcinoma (1973). Tumour Research, 8, 121.
46. Beng, C.G., Chan, G.L., Simons, M.J. and Lau, K.S. (1973). Semi‑quantitation of serum IgE by counterimmunoelectrophoresis. Int. Arch. All. Appl. Immunol., 45, 352‑359.
47. Blake, N.M., McDermid, E.M., Kirk, R.L., Ong, Y.W. and Simons, M.J. (1973). The distribution of red cell enzyme groups among Chinese and Malays in Singapore. Sing. Med. J., 14, 2‑8.
48. Chen, C.Y.H. and Simons, M.J. (1973). Detection of antibodies to seminal plasma in infertile women by counterimmunoelectrophoresis. Proc. 8th Singapore‑Malaysia Congr. of Med. (ed. Tan, N.C.). pp. 295‑299.
49. Chen, C.Y.H. and Simons, M.J. (1973). Rapid detection of antibodies to seminal fluid by counterimmunoelectrophoresis. In: Internatl. Congress Obst. Gyn., Excerpta Medica, ICS, No. 281, p.8.
50. Hawkins, B.R. and Simons, M.J. (1973). Evidence for the existence of the rhesus complex Cde (r') in a Chinese. Vox Sang., 25, 286.
51. Hawkins, B.R., Elliott, M., Kosasih, E.N. and Simons, M.J. (1973). Red cell genetic studies of the Toba Bataks of North Sumatra. Human Biol. Oceania, 2, 147‑154.
52. Kirk, R.L., McDermid, E.M., Blake, N.M., Wight, R.L., Yap, E.H. and Simons, M.J. (1973). The distribution of red cell enzyme and serum protein groups in a population of Dani (Pit River, West Irian). Humangenetik, 17, 345‑350.
53. McDermid, E.M., Blake, N.M., Kirk, R.L., Kosasih, E.N. and Simons, M.J. (1973). The distribution of serum protein and enzyme groups among the Batak of Samosir Island (Nth. Sumatra, Indonesia). Humangenetik, 17, 351‑356.
54. Simons, M.J. and Benedict, A.A. (1974). Radioelectrocomplexing: A general radioimmunoasay procedure for the detection of primary binding of antigen by antibody. In: Contemporary Topics in Molecular Immunology (ed. Ada, G.L.), Plenum Press, New York, 3, ch. 8, 205‑254.
55. Simons, M.J., Wee, G.B., Day, N.E., Morris, P.J., Shanmugaratnam, K. and de The, G.B. (1974). Immunogenetic aspects of nasopharyngeal carcinoma: I. Differences in HLA antigen profiles between patients and control groups. Int. J. Cancer, 13, 122‑134.
56. Simons, M.J., Day, N.E., Wee, G.B., Shanmugaratnam, K., Ho, J.H.C., Wong, S.H., Ti, K.K., Yong, N.K., Dharmalingam, S. and de The, G.B. (1974). Nasopharyngeal carcinoma: V. Immunogenetic studies of South East Asian ethnic groups with high and low risk for the tumour. Cancer Research, 34, 1192‑1195.
57. Simons, M.J. and Hosking, C.S. (1974). AFP and Ataxia‑Telangiectasia. Lancet, 1, 1234.
58. Simons, M.J., Chan, S.H. and Day, N.E. (1974). Genes, Immunity and Nasopharyngeal cancer. In: Cancer Today (eds. Kirk, R.L. and McCullagh, P.), Australian National University Press, pp. 115‑126.
59. Simons, M.J. (1974). Hepatitis B (Australia) antigen. In: Progress in Immunology, vol. 4, Clinical aspects I, (eds. Brent, L. and Holborow, J.), Amsterdam, North‑Holland, pp. 326‑330.
60. Chen, C.Y.H. and Simons, M.J. (1974). Counterimmunoelectrophoresis ‑ a rapid method for the detection of antibodies to seminal plasma. J. Int. Res. Commun., 2, 1647.
61. de The, G.B. and Simons, M.J. (1974). Virologic and Immunogenetic aspects of Nasopharyngeal carcinoma. In: Proc. 11th International Cancer Congress, Florence, Italy. Excerpta Medica, Amsterdam, vol. 6., pp. 123‑127.
62. Hawkins, B.R., Simons, M.J., Goh, E.H., Chia, K.B. and Shanmugaratnam, K. (1974). Immunogenetic aspects of nasopharyngeal carcinoma: II. Analysis of ABO, rhesus, and MNSs red cell systems. Int. J. Cancer, 13, 116‑121.
63. Yap, E.H., Weinhold, D., Malcolm, L.A. and Simons, M.J. (1974). IgE levels in New Guinean highlanders. Papua New Guinea Med. J., 17, 160‑164.
64. Simons, M.J., Day, N.E., Wee, G.B., Chan, S.H., Shanmugaratnam, K. and de The, G.B. (1975). Immunogenetic aspects of nasopharyngeal carcinoma: III. HLA type as a genetic marker of NPC predisposition to test the hypothesis that EBV is an aetiologic factor in NPC. In: Oncogenesis and Herpesviruses II, Part 2, (eds. de The, G.B., Epstein, M.A. and zur Hausen, H.), IARC Publications, Lyon, pp. 249‑258.
65. Simons, M.J., Wee, G.B., Chan, S.H., Shanmugaratnam, K., Day, N.E. and de The, G.B. (1975). Probable identification of an HLA second locus antigen associated with a high risk of Nasopharyngeal carcinoma. Lancet, 1, 142‑3.
66. Simons, M.J., Yu. M. and Shanmugaratnam, K. (1975). Immunodeficiency to Hepatitis B virus infection and genetic susceptibility to development of hepatocellular carcinoma. Ann. NY. Acad. Sci., 259, 181‑195.
67. Simons, M.J. (1975). Transfusion of Hepatitis B immune complex‑containing blood in high HBV prevalence populations. Amer. J. Med. Sci., 270, 349‑354.
68. Simons, M.J. (1975). New concepts in organ transplantation (ed. Raj Mohan Nambiar). Proc. 10th Singapore‑Malaysia Congr. Med., pp. 469‑470.
69. Simons, M.J., Chan, S.H., Ho, J.H.C., Chan, J.C.W., Day, N.E. and de The, G.B. (1975). A Singapore 2‑asssociated LD antigen in Chinese patients with NPC. Proc. 6th Int. Histocompatibility Workshop Conference (ed. Kissmeyer‑Nielson, F.), Munksgaard, pp. 809‑812.
70. Simons, M.J., Chew, T.S., Ee,T.I. and Ong, Y.W. (1975). Hepatitis B antigen‑antibody complexaemia in Singapore blood donors detected by radioelectrocomplexing. In: Hepatitis B; Proc. 1st Australian Hepatitis Symposium (ed. Logan, G.E.), Abbott Laboratories, Sydney, pp. 157‑163.
71. Simons, M.J. (1975). Immunodeficiency to Hepatitis B virus infection and hepatocellular carcinoma. In: Proc. 2nd Asian Cancer Conference, Singapore, pp. 61‑66.
72. Chan, S.H. and Simons, M.J. (1975). Levamisole augmentation of in vitro lymphocyte responsiveness to stimulation by phytohaemagglutinin. Lancet, 1, 1246‑7.
73. Chen, C.Y.H., Simons, M.J., Rajan, S.V. and Ratnam, S.S. (1975). Occurence of antibody to seminal plasma among prostitutes. In: Proc. 10th Singapore‑Malaysia Congr. Med. (ed. Raj Mohan Nambiar), Stamford College Press Pte) Ltd., Singapore, pp.368‑371.
74. de The, G.B., Day, N.E., Geser, A., Lavoue, M.F., Ho, J.H.C., Simons, M.J., Sohier, R., Tukei, P., Vonka, V. and Zavadova, H. (1975). Sero‑epidemiology of the Epstein‑Barr virus: Preliminary analysis of an international study ‑ a review. In: Oncogenesis and Herpesviruses II, Part 2 (eds. de The, G.B., Epstein, M.A. and zur Hausen,H.),IARC Publications, Lyon, pp. 3‑16.
75. de The, G.B. and Simons, M.J. (1975). Nasopharyngeal carcinoma: Evidence for viral and immunogenetic factors. In: Tumours of specific sites (eds. Bucalos, P., Veronesi, U. and Cascinella, N), Excerpta Medica, Amsterdam, 6, 123‑127.
76. de The, G.B., Day, N.E., Geser, A., Ho, J.H.C., Simons, M.J., Sohier, R., Tukei, P. and Vonka, V. (1975). Epidemiology of the Epstein‑Barr virus infection and associated tumours in man. Bibl. Haematol., 43, pp. 216‑220.
77. Goh, E.H., Chan, S.H. and Simons, M.J. (1975). The Mantoux response in NPC. In: Proc. 2nd Asian Cancer Conference, pp. 290‑292.
78. Nishioka, K., Levin, A.G. and Simons, M.J. (1975). Hepatitis B antigen, antigen subtypes, and hepatitis antibody in normal subjects and patients with liver disease. Bull. Wld. Hlth. Org., 52, 293‑300.
79. Tay, C.H., Yap, E.H., Singh, M.L. and Simons, M.J. (1975). Serum IgE levels in normal subjects and allergy patients among the Chinese in Singapore. Ann. Allergy, 35, 312‑
80. Simons, M.J. (1976). Australia (Hepatitis B) Antigen. MD thesis, University of Otago, New Zealand.
81. Simons, M.J. (1976). Immunogenetic‑Immunovirologic strategy in human cancer research: application to nasopharyngeal and hepatocellular carcinoma. D.Med.Sci. thesis, University of Tokyo, Japan.
82. Simons, M.J., Chan, S.H., Wee, G.B. and Mathews, J.D. (1976). HLA and hepatocellular carcinoma in Singapore Chinese. In: Hepatitis Viruses; Proc. Int. Symp. Tokyo, November, 18‑20, 1976 (ed. Japan Medical Research Foundation), Univ. of Tokyo Press, pp. 257‑269.
83. Simons, M.J., Wee, G.B., Chan, S.H., Shanmugaratnam, K., Day, N.E. and de The, G.B. (1976). Immunogenetic aspects of nasopharyngeal carcinoma: IV. Increased risk in Chinese of nasopharyngeal carcinoma associated with a Chinese‑related HLA profile (A2, Singapore 2), J. Natl. Cancer Inst., 57, 977.
84. Chan, S.H., Chew, T.S., Goh, E.H., Simons, M.J. and Shanmugaratnam, K. (1976). Impaired general cell‑mediated immune function in vivo and in vitro in patients with NPC. Int. J. Cancer, 18, 139‑144.
85. Chan, S.H., Lee, S.K. and Simons, M.J. (1976). Levamisole augmentation of lymphocyte hyporesponsiveness to phytohaemagglutinin in patients with pulmonary tuberculosis. Proc. Soc. Exp. Biol. Med., 151, 716‑719.
86 Day, N.E. and Simons, M.J. (1976). Disease susceptibility genes. Identification by multiple case family studies. Tissue Antigens, 8, 109‑119.
87. Hawkins, B.R. and Simons, M.J. (1976). Blood group genetic studies in an urban Chinese population. Human Heredity, 26, 441‑453.
88. Law, C.H., Tan, A.Y.O., Chen, F., Ho, K.T., Leong, S.F., Ng, P.L., Oon, C.J. and Simons, M.J. (1976). Cellular expression of Hepatitis B surface antigen (HBsAg) in liver diseases. In: Proc. 5th Asian Pacific Congr. of Gastroenterology, pp. 290‑293.
89. Simons, M.J., Chan, S.H., Day, N.E., Wee, G.B. and Shanmugaratnam, K. (1977). HLA and nasopharyngeal carcinoma. In: HLA and Malignancy (eds. Murphy, G.P., Cohen, E., Fitzpatrick, J.E. and Pressman, D.); Progr. Clin. Biol. Research, vol. 16, pp. 145‑148.
90. Simons, M.J. and Day, N.E. (1977). Histocompatability leukocyte antigen patterns and nasopharyngeal carcinoma. Natl. Cancer Inst. Monogr., 47, 143‑146.
91. Simons, M.J., Wee, G.B., Singh, D., Dharmalingham, S., Yong, N.K., Chan, J.C.W., Ho, J.H.C., Day, N.E. and de The, G.B. (1977). Immunogenetic aspects of nasopharyngeal carcnoma: V. Confirmation of a Chinese‑related HLA profile (A2, Singapore 2) associated with an increased risk in Chinese for NPC. Natl. Cancer Inst. Monogr., 47, 147‑152.
92. Simons, M.J., Chan, S.H., Day, N.E., Wee, G.B. and Shanmugaratnam, K. (1977). HLA and nasopharyngeal cancer. Progr. Clin. Biol. Res., 16, 145‑148.
93 Chan, S.H. and Simons, M.J. (1977). Immunogenetics of nasopharyngeal carcinoma. Ann. Acad. Med. Singapore, 6, 542‑5466.
94. Chen, C.Y.H., Simons, M.J. and Ratnam, S.S. (1977). Immunity to modified seminal plasma antigens associated with subfertility. Acta Obstet. Gynecol. Scand., 56, 515‑521.
95. Chen, C.Y.H. and Simons, M.J. (1977). Modified seminal plasma antigens and subfertility. In: Immunological influence on human fertility (ed. Boettcher, B.), Academic Press, pp. 251‑261.
96. Chen, C.Y.H. and Simons, M.J. (1977). Modified seminal plasma antigens: further characterisation of antigenic activity. In: Immunological influence on human fertility (ed. Boettcher, B.), Academic Press, pp. 263‑270.
97. Stanley, N.F. and Simons, M.J. (1977). Tropical immunology develops in Australia. Med. J. Aust., 2, 145‑148.
98. Simons, M.J., Chan, S.H., Wee, G.B., Shanmugaratnam, K., Goh, E.H., Ho, J.H.C., Chau, J.C.W., Dharmalingham, S., Prasad, U., Betuel, H., Day, N.E. and de The, G.B. (1978). Nasopharyngeal carcinoma and histocompatibility antigens. In: Nasopharyngeal carcinoma: aetiology and control (eds. de The, G.B. and Ito, Y.), IARC Scientific Publications No. 20, Lyon, pp. 271‑282.
99. Simons, M.J. (1978). Immunological principles in fertility regulation. Ann. Acad. Med. Singapore, 7, 49.
100. Simons, M.J. (1978). HLA genetics, immunity and disease. Papua New Guinea Med. J., 21, 56‑64.
101. Goh, E.H., Chan, S.H. and Simons, M.J. (1978). Effect of levamisole on cell‑mediated immune responses in patients with nasopharyngeal carcinoma. In: Nasopharyngeal carcinoma: aetiology and control (eds. de The, G. B. and Ito, Y.), IARC Scientific Publications No. 20, Lyon, pp. 503‑510.
102. Kirk, R.L., Blake, N.M., Serjeantson, S., Simons, M.J. and Chan, S.H. (1978). Genetic components in susceptibility to nasopharyngeal carcinoma. In: Nasopharyngeal carcinoma: aetiology and control (eds. de The, G.B. and Ito, Y.), IARC Scientific Publications No. 20, Lyon, pp. 283‑297.
103. Simons, M.J. (1979). Interaction between genetic and environmental factors in human cancer. In: Advances in Medical Oncology, Research and Education; vol. 3 ‑ Epidemiology (ed. Birch, J.M.), Pergamon Press, Oxford, pp. 169‑178.
104. Simons, M.J. and Chan, S.H. (1979). Hepatitis B virus and hepatocellular carcinoma. In: Advances in Medical Oncology, Research and Education; vol. 9 ‑ Digestive cancer; liver and pancreatic tumours ‑ oncogenesis (ed. Thatcher, N.), Pergamon Press, Oxford, pp.69‑78.
105 Chan, S.H., Heng, S.H. and Simons, M.J. (1979). Detection of alpha‑fetoprotein by supplementation counterimmunoelectrophoresis (CIE). J. Immunol. Methods, 29, 191‑196.
106. Chan, S.H., Wee, G.B., Srinivasan, N., Glen, S.P.P., Cheng, P., Vengadasalam, D., Alano, F.A. and Simons, M.J. (1979). HLA antigens in three common populations in South East Asia ‑ Chinese, Malay and Filipino. Tissue Antigens, 13, 361‑368.
107. Marks, R. and Simons, M.J. (1979). Geographical tongue ‑ a manifestation of atopy. Br. J. Dermatol., 101, 159‑62.
108. Shanmugaratnam, K., Chan, S.H., de The, G.B., Goh, J.E.H., Khor, T.H., Simons, M.J. and Tye, C.Y. (1979). Histopathology of nasopharyngeal carcinoma: correlations with epidemiology, survival rates and other biological characteristics. Cancer, 44, 1029‑1044.
109. Simons, M.J. (1980). Immunogenetics and disease. In: Tropical immunology; research for development, seminar three (ed. Davidson, L.), Commonwealth Institute of Health, University of Sydney, pp. 120‑128.
110. Chan, S.H., Simons, M.J. and Oon, C.J. (1980). HLA antigens in Chinese patients with hepatocellular carcinoma. J. Natl. Cancer Inst., 65, 21‑23.
111. Chan, S.H., Chen, F., Chio, L.F., Ho, K.T., Law, C.H., Leong, S.F., Mathew, T., Ng, P.L., Oon, C.J., Seah, C. S., Simons, M.J., Tan, A.Y.O. and Tan, I.K. (1980). Hepatitis B virus and alpha‑foetoprotein in liver diseases in Singapore. Sing. Med. J., 21, 506‑508.
112. Daveau, M., Rivat, L., Lalouel, J.M., Langaney, A., Roberts, D.F. and Simons, M.J. (1980). Frequencies of Gm and Km allotypes in the population of Singapore, Sri Lanka and Punjabis in North India. Hum. Hered., 30, 237‑244.
113. Simons, M.J. (1981). Nasopharyngeal carcinoma, including analysis of HLA gene patterns in Chinese patients with cervical and hepatocellular carcinoma. In: Proc. 2nd Asia‑Oceania Histocompatibility Workshop Conference (eds. Simons, M.J. and Tait, B.D.), Immunopublishing, Melbourne, pp. 369‑378.
114. Simons, M.J. (1981). Cervical carcinoma. In: Proc. 2nd Asia‑Oceania Histocompatibility Workshop Conference (eds. Simons, M.J. and Tait, B.D.), Immunopublishing, Melbourne, pp. 363‑366.
115. Simons, M.J. and Tait, B.D. (1981). Proc. 2nd Asia‑Oceania Histocompatibility Workshop Conference (eds). Immunopublishing, Melbourne.
116. Tait, B.D., Finlay, R.I. and Simons, M.J. (1981). Serum HLA typing. Tissue Antigens, 17, 129‑135.
117. Simons, M.J. and Shanmugaratnam, K. (1982). The biology of nasopharyngeal carcinoma (eds). UICC Technical Report Series, Geneva, vol. 71.
118. Propert, D.N., Bernard, C.C. and Simons, M.J. (1982). Gm allotypes and multiple sclerosis. J. Immunogenet. 9, 359‑361.
119. Chan, S.H., Day, N.E., Kunaratnam N., Chia, K.B. and Simons, M.J. (1983). HLA and nasopharyngeal carcinoma in Chinese ‑ a further study. Int. J. Cancer, 32, 171‑176.
120. Simons, M.J. and Tait, B.D. (1984). Detection of immune‑associated genetic markers of human disease. Practical Methods in Clinical Immunology Series, vol. 7, Churchill Livingstone, Edinburgh, pp. 1‑147.
121. Simons, M.J. (1985). Epstein‑Barr Virus and Associated Diseases. (Proc. 1st Int. Symp. on EBV‑associated Malignant Diseases). Devel. in Med. Virology, vol. 1 (eds. Levine, P.H., Ablashi, D.V., Pearson, G.R. and Kottaridis, S.D.), Martinus Nijhoff, Boston. pp. 90‑105.
122. McKnight, B., Lu, S.T., Ju, L., Day, N.E., Degos, L., Lepage, V., Chan, S.H., Prasad, U., Ho, J.H.C., Simons, M.J., Zeng, Y. and de The, G. (1987). A Preliminary analysis of HLA studies of multiple NPC cases among siblings from the People's Republic of China, Hong Kong, Singapore and Malaysia. (Proc. 2nd. Int. Symp. on EBV‑associated Malignant Diseases). Devel. in Med. Virology, vol. 2 .
123. Simons, M. J. (1989). DNA Gene Typing in Disputed Paternity Resolution. Australian Family Lawyer, 4, (3):15-18.
124. Dupont, B., Simons, M.J., Wheelers, R., Ferguson, M., & Lalouel, J-M. (1989) A display of positive correlations obtained by serology, Southern blot analysis, T-lymphocyte clones, and two-dimensional gel analysis tested on reference panel of B-lymphoblastoid cell lines for factors of the HLA system. In Dupont, B., (ed): Immunobiuology of HLA, Vol. 1: Histocomptibility testing 1987. New York: Springer-Verlag, pp. 1035-1067.
125. Simons, M.J., Wheeler. R., Coyhen. D., Lalouel, J-M., and Dupont, B. (1989) Restriction fragment length polymorphism of HLA genes. Summary of the Tenth International Workshop Southern blot analysis. In: Dupont, B. (ed) Immunobiology of HLA, Vol. 1: Histcompatability testing 1987. New York:Springer-Verlag. pp 959-1023.
126. Simons, M.J. & Erlich, H.A. (1989) RFLP - sequence interrelations at the DPA and loci. In: Dupont, B. (ed) Immunobiology of HLA. Vol. 1: Histocompatability testing 1987. New York: Springer-Verlag. 959-959.
127. Cohen Daniel, Simons M.J., J-M Lalouel, and Dupont, B. (1989) Nomenclature for HLA-RFLP International Workshop. Immunobiology of HLA. Vol 1: Histocompatability testing 1987. New York Springer-Verlag, 67.
128. Simons, M. J. (1990) HLA DNA identityping. In: Robertson, J., Ross, A. M. and Burgoyne, L. A., eds. DNA in Forensic Science. Ellis Horwood Limited. pp. 124-140.
129. Simons, M.J., Limm, T.M., Naughton, M.J., Quinn, D.L., McGinnis, M.D., Ashdown, M.L., (1993) Strategy for Definition of DR/DQ Haplotypes in the 4AOHW Cell Panel Using Noncoding Sequence Polymorphisms. Human Immunology Vol 38. American Society for Histocompatibility and Immunogenetics. pp. 69-74.
130. Limm, T.M., Ashdown, M.L., Naughton, M.J., McGinnis, M.D., Simons, M.J., (1993) HLA-DLQA1 Allele and Suballel Typing Using Noncoding Sequence Polymorphisms. Application to 4AOHW Cell Panel Typing. Human Immunology Vol 38. American Society for Histocompatibility and Immunogenetis. pp. 57-88.
131. Degli-Esposti, M.A., Griffiths, M.S.J., Daly, L.N., Witt, C.S., Simons, M.J., Carcassi, C., Ekkehard, A.D., Giphart, M.J., Dawkins, R.J., (1993) Characterization of 4AOHW Cell Line Panel Including New Data for the 101HW Panel. Human Immunology Vol 38. American Society for Histocompatibility and Immunogenetics. pp.3-16.
132. Naughton, M.J., Limm, T.M., Ashdown, M.L., Simons, M.J., (1994) DPB1 Locus PCR-RFLP Typing of the Fourth Asia-Oceania Histocompatibility Workshop Cell Panel Reveals A Novel DPB1 Allele. European Journal of Immunogenetics (Vol 21). pp.351-364.
133. McGinnis, M.D., Lebo, R.V., Quinn. D.L., Simons, M.J., (1994) Ancient, Highly Polymorphic Human Major Histocompatibility Complex DQA1 Intron Sequences. American Journal of Medical Genetics Vol 52. pp. 438-444.
134. Malcolm J. Simons, Alexandra Gavrilidis, Melinda J. Naughton Teresa M. Limm and M. Luisa Ashdown, (1995), A Marmoset in the Aseatta QC Program. Aseatta Newsletter (Vol 20) No 2,pp.26-33.
135. Gavrilidis, A.,Naughton, M.J., Ashdown, M.L. & Simons, M.J.(1996) HLA DRB1 Locus Sequence Typing. Aseatta Newsletter (Vol 21) No 1, pp.22-23.
ASEATTA, 1996 Annual Scientific Meeting. Beyond 12 IW: MHC Molecular Medicine into the 21st Century.
136. Simons M.J., Gavrilidis, A., M.L. Ashdown, (1996) ABSTRACT 16. The Utility of Intron Sequences for HLA Typing and HaploTyping.
137. Simons M.J., (1996) ABSTRACT 50. 10TH IHW RFLP REVISITED: yes, there was a DNA era before PCR.
138. Simons M.J. (1996) ABSTRACT 51. Haemachromatosis Gene - "A Novel MHC Class 1 - like gene "?.
139. Simons M.J., Wood, J.M., Gavrilidis, A., Sebalj, S and Ashdown, M.L. (1998) ABSTRACT 39. HLA HaploTyping using non-coding polymorphisms. Presented at 24th Annual Meeting, American Society for Histocompatibility and Immunogenetics October 1998 and 4th Chromosome 6 Workshop, The Sanger Centre, Wellcome Trust Genome Campus, Cambridge U.K., June 1999.
140. Simons M.J., (2003), HLA and Nasopharyngeal Carcinoma: 30 Years On
American Society for Histocompatibility and Immunogenetics Quarterly, 2nd
Quarter, 2003; 27(2): 52-55
140. Wood J.M., Ashdown M.L. and Simons M.J. (1999) HLA DPB1/DPA1 haplotype-associated non-coding polymorphisms: Discovery of a mongoloid haplotype sequence unique among Homo sapiens. Presented at Annual Scientific Meeting of Australasian and South East Asian Tissue Typing Association (ASEATTA), Auckland, New Zealand.
141. Nature (June 1999) Poster, “Gene Map of the Human Major Histocompatibility Complex.
142. Simons, M.J. (2003) HLA and Nasopharyngeal Carcinoma: 30 Years On. American Society for Histocompatibility and Immunogenetics (ASHI) Quarterly (Second Quarter 2003), 27(2);52-55.
143. Simons, M.J. (2004). ‘Junk DNA’ Non-Coding Patents: The Inventor’s View. Nature Genetics (accepted for publication). |
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